Portuguese GP
 Algarve International Circuit – Portimão
Round 3 - MotoGP 2021. Apr 16th, 2021 - Apr 18th, 2021
Gran Premio Red Bull de España
 Circuito de Jerez
Round 4 - MotoGP 2021. Apr 30th, 2021 - May 2nd, 2021
Grand Prix de France
 Automobile Club de l’Ouest Le Mans
Round 5 - MotoGP 2021. May 14th, 2021 - May 16th, 2021
Gran Premio d’Italia
 Mugello Circuit
Round 6 - MotoGP 2021. May 28th, 2021 - May 30th, 2021
Gran Premi de Catalunya
 Circuit de Barcelona – Catalunya
Round 7 - MotoGP 2021. Jun 4th, 2021 - Jun 6th, 2021
Motorrad Grand Prix Deutschland
 Sachsenring
Round 8 - MotoGP 2021. Jun 18th, 2021 - Jun 20th, 2021
Motorrad Grand Prix von Österreich
 Red Bull Ring – Spielberg
Round 11 - MotoGP 2021. Aug 13th, 2021 - Aug 15th, 2021
Gran Premio de Aragón
 Motorland Aragon
Round 13 - MotoGP 2021. Sep 10th, 2021 - Sep 12th, 2021
Gran Premio di San Marino e della Riviera di Rimini
 Misano World Circuit
Round 14 - MotoGP 2021. Sep 17th, 2021 - Sep 19th, 2021
Thailand Grand Prix
 Chang Internation Circuit
Round 16 - MotoGP 2021. Oct 8th, 2021 - Oct 10th, 2021
Australian Motorcycle Grand Prix
 Phillip Island Circuit
Round 17 - MotoGP 2021. Oct 22nd, 2021 - Oct 24th, 2021
Malaysia Motorcycle Grand Prix
 Sepang Circuit
Round 18 - MotoGP 2021. Oct 29th, 2021 - Oct 31st, 2021
Gran Premio de la Comunitat Valenciana
 Comunitat Valenciana
Round 19 - MotoGP 2021. Nov 12th, 2021 - Nov 14th, 2021